From best-in-class science to best-in-class therapies.

Our Science

Treating Serious Diseases.

Akero Therapeutics is committed to providing meaningful treatment options for people with serious metabolic diseases like non-alcoholic steatohepatitis (NASH), a disease marked by inflammation in the liver and liver cell damage resulting in fibrosis, cirrhosis, liver failure and death.

Over the past decade, scientists have determined that the endogenous hormone fibroblast growth factor 21 (FGF21) plays a critical role in the regulation of metabolism and signaling throughout the body, acting on multiple organ systems, including the liver. The body naturally recruits FGF21 to restore health to distressed organs and ensure balance across metabolic pathways.

Akero’s lead clinical program, AKR-001 is a novel, long-acting Fc fusion modified FGF21 agonist and potential best-in-class treatment for NASH. AKR-001 builds upon two decades of work on FGF21 biology and is designed to affect both the liver and adipose tissue, reducing liver fat and suppressing inflammation and fibrosis.

AKR-001 was well tolerated in early clinical studies, and showed positive effects on key biomarkers of metabolic and cardiovascular disease. Akero plans to initiate Phase 2 clinical studies of AKR-001 for the treatment of NASH and is evaluating its potential to treat other serious metabolic diseases.

As many as 1 in 7 people in developed countries may be living with NASH.
Prevalence rates are quickly rising across the globe, as a result of the worldwide increase of obesity.

Related Publications

This page contains links to articles written by persons not affiliated with Akero Therapeutics. These third-party articles are identified for background and historical purposes only, and Akero does not purport that they represent a complete survey of the relevant science. The views expressed in the articles are those of their respective authors and do not reflect the views of Akero. Akero has not independently verified any of the information contained in the third-party articles and disavows any obligation to update or correct the information contained in these articles.