Our current focus is on non-alcoholic steatohepatitis (NASH), a severe form of non-alcoholic fatty liver disease marked by whole-body metabolic dysregulation with multiple, complex disease drivers that also increase the risk of cardiovascular disease. NASH is caused by excessive caloric overburdening in the liver, which leads to excess storage of fat in the liver and stress on liver cells called hepatocytes. Hepatocyte cell stress, injury and death leads to liver inflammation, which may cause fibrosis (scarring).

Ultimately, liver fibrosis may progress to cirrhosis (severe scarring) and liver cancer. People with NASH and mild liver scarring (fibrosis) may or may not experience symptoms, but severe scarring (cirrhosis) increases risk of liver failure and death.

Effective treatment of NASH requires intervening across stages of disease progression, addressing both the early-stage metabolic drivers and later-stage inflammation and fibrosis

We believe restoring whole-body metabolic balance is essential to treating NASH. Our lead program, EFX, has yielded promising data showing potential to address the diverse drivers of NASH pathology.