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Publications & posters

Our drug R&D is supported by scientific research published by the Akero team, our collaborators, and by external experts.

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Jul 2018 | FROM EXTERNAL EXPERTS

A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling

Shi, S.Y. et al. Scientific Reports

Jul 2018 | From External Experts

FGF21 gene therapy as treatment for obesity and insulin resistance

Jimenez, V., et al EMBO Molecular Medicine

Jun 2018 | FROM EXTERNAL EXPERTS

Recent advances in understanding and managing non-alcoholic fatty liver disease

Albhaisa, S., Sanyal A. F1000 Research

Feb 2018 | From External Experts

LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice

Le, C.T., et al PLoS One

Jan 2018 | From External Experts

Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

Lee, S., et al Nature

Jan 2018 | FROM EXTERNAL EXPERTS

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

Estes, C. et al. Hepatology

May 2017 | FROM EXTERNAL EXPERTS

A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys

Stanislaus, S. et al. Endocrinology

Apr 2017 | FROM EXTERNAL EXPERTS

FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists

Li, X. et al. Journal of Bone and Mineral Research

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Our comprehensive clinical program is designed to evaluate EFX as a potential treatment for MASH.

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