Efruxifermin Publications
AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients
Kaufman, A. et al. (2020) Cell Rep Med
Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
Byun, S. et al. (2020) Nat. Commun
Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma
Hatlen, M. et al. (2019) Cancer Discov
LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice
Le CT et al. (2018) PLOS ONE
Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial
Sanyal A et al. (2018) Lancet
FGF21 gene therapy as treatment for obesity and insulin resistance
Jimenez V et al. (2018) EMBO Mol Med
A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling
Shi S et al. (2018) Sci Rep
A long-acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis partly through an FGF21-adiponectin-IL17A pathway
Bao L et al. (2018) British J Pharmacol
Recent advances in understanding and managing non-alcoholic fatty liver disease
Albhaisi S and Sanyal A (2018) F1000Res
FGF21 acts as a negative regulator of bile acid synthesis
Chen MM et al. (2018) J Endocrinol
Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signaling
Lee S et al. (2018) Nature
Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease
Estes C et al. (2018) Hepatol
A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys
Stanislaus S et al. (2017) Endocrinol
FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists
Li X et al. (2017) J Bone Miner Res
Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury
Desai BN et al. (2017) Mol Metab
Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-κB signaling pathway
Yu Y et al. (2016) Int. Immunopharmacol
An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by enhancing hepatic mitochondrial function
Lee JH et al. (2016) Am J Translational Res
Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways
Xu P et al. (2016) Toxicol & Applied Pharmacol
Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders
Zhang J et al. (2015) Front Endocrinol
Fibroblast Growth Factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets
Fisher FM et al. (2014) Gastroenterology
Fibroblast growth factor receptor 4 (FGFR4) deficiency improves insulin resistance and glucose metabolism under diet-induced obesity conditions
Ge, H et al. (2014) J Biol Chem
Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice
Yu X et al. (2013) PLOS ONE
Published Amgen synopses of AKR-001 Phase 1 clinical trials
Amgen (2013/2015) Amgen Clinical Trials
Dual actions of fibroblast growth factor 19 on lipid metabolism
Wu X et al. (2013) J Lipid Res
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models–association with liver and adipose tissue effects
Xu et al. (2009) Am J Physiol Endocrinol Metab
Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice
Wu X et al. (2009) Proc Natl Acad Sci USA
Fibroblast Growth Factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
Xu J et al. (2009) Diabetes
FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver
Huang X et al. (2007) Diabetes
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.
Kharitonenkov A et al. (2007) Endocrinol